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The Key to Clean in Place (CIP) is Good Process Design

CIP is the foundation process in modern aseptic facilities. Good CIP designs provide for efficient, repeatable, and validateable cleaning of aseptic systems. A good CIP system design includes a comprehensive CIP skid at its heart, and the skid’s design must address all the equipment to be cleaned: tanks, piping, valves, hoses, mixers, blenders, centrifuges, instrumentation sensors, ad infinitum. The task…

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ASEPCO Takeoff Valves Kill Dead Legs at “Tees”

The ASEPCO Weirless Radial-Diaphragm Takeoff Valve Family is suited for any critical CIP/SIP application where a “tee” and its associated dead leg must be eliminated. Key applications include: point of use or “drops” for pure waters (including WFI) as well as sampling, draining, transferring, or diverting from a line or manifolds. The two ASEPCO valves in this family are the…

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Quality By Design

One of the cornerstones of our industry is quality; from raw materials to end products, maintaining quality is important. It isn’t important just because supplying a quality product satisfies customers, but also because good quality reduces risk. When you look at a product, like a valve, there are many different aspects to ensuring the quality of the product matches your…

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What You Need to Know About Corrosion Resistance

As the bioprocessing industry continues to evolve and improve its processes, we all need to be aware of the challenges this evolution may create for systems and equipment, including the materials used to build these systems and equipment. One of the specific areas to keep an eye on is corrosion resistance. Choosing the right material is a balancing act between…

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Answering Your Questions About Our Diaphragms

We recently received feedback from a customer on one of our diaphragm articles. We felt their comments were important enough to address with all our customers. “Did Asepco really change nothing in the formulation or manufacturing process of the diaphragm?” Since we began making products for the bioprocessing industry over 25 years ago, we have always been very aware of…

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Comparing Permanent, Single-Use, and Hybrid Systems

During the last decade, the push within the biopharmaceutical industry has been three-fold: increase capacity, gain flexibility, and decrease costs. All of these factors have led to the adoption of single-use systems (SUS) in biopharmaceutical manufacturing; however, complete adoption of an SUS may not be the best plan. There are still situations in which stainless steel has advantages. We have…

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Biopharm Process Evolution vs. Plant Evolution

We have a story that we tell to new employees who need to understand the challenges of supplying and using equipment in the bioprocessing industry. It is about one of our favorite customers who has used our products for years. One day, years ago, they called us to their facility. They took us to a conference room, and then they…

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Valve Basics

Like any other well-established technology, valves have a wide variety of designs and options. At times, this variety can make it difficult to compare valves. In the spirit of National Mentoring Month, we thought we’d introduce you to some valve basics, from terminology to use. While there are many types of valves, in this article we’ll focus on diaphragm valves…

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Divert Valve: A Detailed Look

In a process system, there is often a need to switch flow from one process stream to another. One of the ways this can be done is with a valve assembly called a divert valve. Understanding the details of a divert valve assembly can help ensure that you not only get the most cost-effective solution for your process, but that…

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Block Bodies: A Steady Revolution in Valve Design

One of the hallmarks of the biopharmaceutical industry is constant innovation that supports the industry goal of helping people live longer, healthier lives. These innovations are spread throughout the industry from the science behind new drugs to advancements in processing equipment. Sometimes changes are subtle, other times they are dramatic. One of the subtle changes has been the constant, ceaseless…

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